Effect of changing transit time on colonic microbial metabolism in man.

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Effect of changing transit time on colonic microbial metabolism in man.

An investigation was made of the effect of changing mean transit time (MTT) by administration of drugs which affect colonic motility on faecal microbial mass in man. Senokot was used to accelerate and codeine and/or loperamide to prolong transit in subjects maintained on a constant high fibre diet. Doses of Senokot or codeine/loperamide were adjusted to halve or double transit time measured dur...

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Measurement of colonic transit time with Transit-PelletsmethodTM

About 20% of the population suffer from constipation. For the common types of functional constipation, idiopathic and IBS related constipation, the proportion of women is about 80-90%. It is important to structure the management of this large patient group. The duration of symptoms is of relevance. In general, a long history allows for more restricted investigations, and the management can be f...

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Effect of yacon (Smallanthus sonchifolius) on colonic transit time in healthy volunteers.

BACKGROUND Yacon is a root crop which contains high amounts of fructooligosaccharides (FOS). The aim of this study was to investigate the effects of yacon syrup on colon transit time in healthy volunteers. METHODS In a placebo-controlled, double-blind study yacon was administered to 16 healthy individuals (8 males, 8 females) in a dose of 20 g daily (equal to 6.4 g FOS) in a 2-week crossover ...

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Effect of tegaserod on colonic transit time in male patients with constipation-predominant irritable bowel syndrome.

BACKGROUND AND AIMS Tegaserod is approved for the treatment of constipation-predominant irritable bowel syndrome (C-IBS) in females. The aim of this study was to evaluate the effect of tegaserod on colonic transit time (CTT) and symptoms in male patients with C-IBS. METHODS Forty-four males with C-IBS (Rome II) were enrolled. After a baseline washout period of 2 weeks, 40 patients were random...

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ژورنال

عنوان ژورنال: Gut

سال: 1987

ISSN: 0017-5749

DOI: 10.1136/gut.28.5.601